Structure analysis

Probable 2-hydroxyacid dehydrogenase from Rhizobium etli CFN 42 in complex with NADPH

X-ray diffraction
1.4Å resolution
Source organism: Rhizobium etli CFN 42
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 26400 Å2
Buried surface area: 8200 Å2
Dissociation area: 2,400 Å2
Dissociation energy (ΔGdiss): 18 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -44 kcal/mol
Symmetry number: 2

Macromolecules

Chain: A
Length: 320 amino acids
Theoretical weight: 35.52 KDa
Source organism: Rhizobium etli CFN 42
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2KDT2 (Residues: 1-319; Coverage: 100%)
Gene name: RHE_CH00179
Pfam: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain

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