› › Structure analysis

Probable 2-hydroxyacid dehydrogenase from Rhizobium etli CFN 42 in complex with NADPH

X-ray diffraction
1.4Å resolution
PDB 4xcv coloured by chain and viewed from the front.
PDB 4xcv coloured by chain and viewed from the side.
PDB 4xcv coloured by chain and viewed from the top.
Source organism: Rhizobium etli CFN 42
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 26400 Å2
Buried surface area: 8200 Å2
Dissociation area: 2,400 Å2
Dissociation energy (ΔGdiss): 18 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -44 kcal/mol
Symmetry number: 2

Macromolecules

2-Hacid_dh_C domain-containing protein
Chain: A
Length: 320 amino acids
Theoretical weight: 35.52 KDa
Source organism: Rhizobium etli CFN 42
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2KDT2 (Residues: 1-319; Coverage: 100%)
Gene name: RHE_CH00179
Pfam: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
PDB 4xcv contains 2 copies of NADP-dependent 2-hydroxyacid dehydrogenase in assembly 1. This protein is highlighted and viewed from the front.
PDB 4xcv contains 2 copies of NADP-dependent 2-hydroxyacid dehydrogenase in assembly 1. This protein is highlighted and viewed from the side.
PDB 4xcv contains 2 copies of NADP-dependent 2-hydroxyacid dehydrogenase in assembly 1. This protein is highlighted and viewed from the top.
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