› 4x5y

X-ray diffraction
1.59Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Menin Chain: A
Molecule details ›
Chain: A
Length: 489 amino acids
Theoretical weight: 54.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00255 (Residues: 1-432, 542-598; Coverage: 74%)
Gene names: MEN1, SCG2
Sequence domains: Menin

Ligands and Environments

6 bound ligands:
Ligand 3XW 1 x 3XW
Ligand DMS 3 x DMS
Ligand PG4 1 x PG4
Ligand SO4 3 x SO4
Ligand EDO 1 x EDO
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 48.378Å b: 79.732Å c: 124.747Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.206
Expression system: Escherichia coli

Quick links

Citations

70 review citations

Emerging Targeted Therapy for Specific Genomic Abnormalities in Acute Myeloid Leukemia.
Chi et al. (2022)
69 more

8 mentions without citation

A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia.
Ozyerli-Goknar et al. (2021)
7 more