4x4m

X-ray diffraction
3.48Å resolution

Structure of FcgammaRI in complex with Fc reveals the importance of glycan recognition for high affinity IgG binding

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 219 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01857 (Residues: 112-330; Coverage: 66%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
High affinity immunoglobulin gamma Fc receptor I Chains: E, F
Molecule details ›
Chains: E, F
Length: 275 amino acids
Theoretical weight: 31.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12314 (Residues: 21-289; Coverage: 75%)
Gene names: FCG1, FCGR1, FCGR1A, IGFR1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 59.921Å b: 67.991Å c: 125.028Å
α: 89.86° β: 112.25° γ: 89.96°
R-values:
R R work R free
0.249 0.245 0.296
Expression systems:
  • Cricetulus griseus
  • Escherichia coli