X-ray diffraction
1.05Å resolution

Function and Biology Details

Reaction catalysed:
1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 25.91 KDa
Source organism: Actinomyces urogenitalis DSM 15434
Expression system: Escherichia coli
  • Canonical: C0W7K4 (Residues: 1-247; Coverage: 100%)
Gene names: HMPREF0058_1848, hisA
Sequence domains: Histidine biosynthesis protein
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41
Unit cell:
a: 76.02Å b: 76.02Å c: 43.179Å
α: 90° β: 90° γ: 90°
R R work R free
0.123 0.123 0.141
Expression system: Escherichia coli