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Crystal Structure of Human Aldehyde Dehydrogenase, ALDH1a2

X-ray diffraction
2.94Å resolution
PDB entry 4x2q coloured by chain, front view.
PDB entry 4x2q coloured by chain, side view.
PDB entry 4x2q coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Retinal dehydrogenase 2
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Multimeric state: homo tetramer
Accessible surface area: 66599.92 Å2
Buried surface area: 21072.18 Å2
Dissociation area: 4,839.15 Å2
Dissociation energy (ΔGdiss): 27.72 kcal/mol
Dissociation entropy (TΔSdiss): 16.69 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-131758

Macromolecules

Retinal dehydrogenase 2
Chains: A, B, C, D
Length: 504 amino acids
Theoretical weight: 55.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94788 (Residues: 21-518; Coverage: 96%)
Gene names: ALDH1A2, RALDH2
Pfam: Aldehyde dehydrogenase family
InterPro:
CATH:
Retinal dehydrogenase 2 in PDB entry 4x2q, assembly 1, front view.
Retinal dehydrogenase 2 in PDB entry 4x2q, assembly 1, side view.
Retinal dehydrogenase 2 in PDB entry 4x2q, assembly 1, top view.
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