4x21

X-ray diffraction
1.95Å resolution

The MAP kinase JNK3 as target for halogen bonding

Released:
Source organism: Homo sapiens
Entry authors: Lange A, Buettner FM, Guenther MB, Zimmermann MO, Hennig S, Laufer SA, Stehle T, Boeckler F

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 367 amino acids
Theoretical weight: 42.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53779 (Residues: 39-402; Coverage: 78%)
Gene names: JNK3, JNK3A, MAPK10, PRKM10, SAPK1B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21212
Unit cell:
a: 155.94Å b: 109.84Å c: 43.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.2 0.224
Expression system: Escherichia coli BL21(DE3)