X-ray diffraction
2.17Å resolution

Structural basis for mutation-induced destabilization of Profilin 1 in ALS


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Profilin-1 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P07737 (Residues: 1-140; Coverage: 100%)
Gene name: PFN1
Sequence domains: Profilin
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 73.65Å b: 31.712Å c: 60.539Å
α: 90° β: 122.03° γ: 90°
R R work R free
0.197 0.196 0.214
Expression system: Escherichia coli BL21(DE3)