› 4wzg

X-ray diffraction
1.9Å resolution

Structure of human ATG101

Released:
DOI: 10.2210/pdb4wzg/pdb
PDB entry 4wzg coloured by chain, front view.
PDB entry 4wzg coloured by chain, side view.
PDB entry 4wzg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The mammalian autophagy initiator complex contains 2 HORMA domain proteins.
Michel M, Schwarten M, Decker C, Nagel-Steger L, Willbold D, Weiergräber OH
Autophagy 11 2300-8 (2015)
PMID: 26236954

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189704 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Autophagy-related protein 101 Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 25.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BSB4 (Residues: 1-218; Coverage: 100%)
Gene names: ATG101, C12orf44, PP894
Sequence domains: Autophagy-related protein 101

Ligands and Environments

1 bound ligand:
Ligand BME 1 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P2
Unit cell:
a: 40.15Å b: 42.62Å c: 67.21Å
α: 90° β: 97.31° γ: 90°
R-values:
R R work R free
0.199 0.198 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Mechanisms of Autophagy Initiation.
Hurley et al. (2017)
7 more

3 mentions without citation

Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.
Qi et al. (2015)
2 more