4wxx

X-ray diffraction
2.62Å resolution

The crystal structure of human DNMT1(351-1600)

Released:
Source organism: Homo sapiens
Entry authors: Zhang ZM, Song J

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA (cytosine-5)-methyltransferase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1256 amino acids
Theoretical weight: 142.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26358 (Residues: 351-1600; Coverage: 77%)
Gene names: AIM, CXXC9, DNMT, DNMT1
Sequence domains:

Ligands and Environments


Cofactor: Ligand SAH 2 x SAH
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P43
Unit cell:
a: 138.568Å b: 138.568Å c: 221.536Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.245
Expression system: Escherichia coli