X-ray diffraction
3.2Å resolution

Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein

Source organism: Homo sapiens
Entry authors: Bokhove M, De Sanctis D, Jovine L

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Maltose/maltodextrin-binding periplasmic protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 695 amino acids
Theoretical weight: 76.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: P0AEX9 (Residues: 27-393; Coverage: 99%)
Gene names: JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: R32
Unit cell:
a: 242.32Å b: 242.32Å c: 258.86Å
α: 90° β: 90° γ: 120°
R R work R free
0.222 0.221 0.246
Expression system: Homo sapiens