Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
- not assigned
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139518 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Macrophage colony-stimulating factor 1 receptor
Molecule details ›
Chains: A, C
Length: 286 amino acids
Theoretical weight: 31.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins
Length: 286 amino acids
Theoretical weight: 31.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P07333 (Residues: 20-296; Coverage: 29%)
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins
Macrophage colony-stimulating factor 1 43 kDa subunit
Molecule details ›
Chains: B, D
Length: 170 amino acids
Theoretical weight: 19.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Macrophage colony stimulating factor-1 (CSF-1)
Structure domains: Growth Hormone; Chain: A;
Length: 170 amino acids
Theoretical weight: 19.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P09603 (Residues: 33-181; Coverage: 29%)
Sequence domains: Macrophage colony stimulating factor-1 (CSF-1)
Structure domains: Growth Hormone; Chain: A;
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID23-1
Spacegroup:
I41
Expression systems:
- Homo sapiens
- Escherichia coli
