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Crystal Structure of Surfactant Protein-A DEDN Mutant (E171D/P175E/R197N/K203D) Complexed with Inositol

X-ray diffraction
1.751Å resolution
PDB entry 4wre coloured by chain, front view.
PDB entry 4wre coloured by chain, side view.
PDB entry 4wre coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pulmonary surfactant-associated protein A
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Multimeric state: homo trimer
Accessible surface area: 19343.8 Å2
Buried surface area: 6892.35 Å2
Dissociation area: 2,150.56 Å2
Dissociation energy (ΔGdiss): 25.93 kcal/mol
Dissociation entropy (TΔSdiss): 24.49 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-140125

Macromolecules

Pulmonary surfactant-associated protein A
Chain: A
Length: 148 amino acids
Theoretical weight: 16.63 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P08427 (Residues: 101-248; Coverage: 65%)
Gene names: Sftp-1, Sftp1, Sftpa, Sftpa1
Pfam: Lectin C-type domain
InterPro:
CATH: Mannose-Binding Protein A, subunit A
Pulmonary surfactant-associated protein A in PDB entry 4wre, assembly 1, front view.
Pulmonary surfactant-associated protein A in PDB entry 4wre, assembly 1, side view.
Pulmonary surfactant-associated protein A in PDB entry 4wre, assembly 1, top view.
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