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Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, apo form

Source organism: Klebsiella pneumoniae
Biochemical function: metal ion binding
Biological process: response to antibiotic
Cellular component: not assigned

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EC 2.7.7.46: Gentamicin 2''-nucleotidyltransferase

Reaction catalysed:
Nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin
Systematic name:
NTP:gentamicin 2''-nucleotidyltransferase
Alternative Name(s):
  • 2''-aminoglycoside nucleotidyltransferase
  • Aminoglycoside adenylyltransferase
  • Gentamicin 2''- adenylyltransferase
  • Gentamycin 2''-nucleotidyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF10706
Domain description: Aminoglycoside-2''-adenylyltransferase
Occurring in:
  1. 2''-aminoglycoside nucleotidyltransferase
The deposited structure of PDB entry 4wqk contains 1 copy of Pfam domain PF10706 (Aminoglycoside-2''-adenylyltransferase) in 2''-aminoglycoside nucleotidyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR019646
Domain description: Aminoglycoside-2''-adenylyltransferase
Occurring in:
  1. 2''-aminoglycoside nucleotidyltransferase

Structure domain

CATH CATH domain
3.30.460.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta Polymerase; domain 2
Homology: Beta Polymerase; domain 2
Occurring in:
  1. 2''-aminoglycoside nucleotidyltransferase
The deposited structure of PDB entry 4wqk contains 1 copy of CATH domain 3.30.460.40 (Beta Polymerase; domain 2) in 2''-aminoglycoside nucleotidyltransferase. Showing 1 copy in chain A.

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