PDBe 4wlb

X-ray diffraction
1.7Å resolution

Crystal structure of RORc in complex with a partial inverse agonist compound

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor ROR-gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 265 amino acids
Theoretical weight: 30.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51449 (Residues: 262-507; Coverage: 48%)
Gene names: NR1F3, RORC, RORG, RZRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
SRC-1 peptide Chains: D, E
Molecule details ›
Chains: D, E
Length: 8 amino acids
Theoretical weight: 931 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 66.787Å b: 86.258Å c: 91.854Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.178 0.226
Expression systems:
  • Escherichia coli
  • Not provided