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Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A

X-ray diffraction
1.37Å resolution
PDB entry 4wkb coloured by chain, front view.
PDB entry 4wkb coloured by chain, side view.
PDB entry 4wkb coloured by chain, top view.
Source organism: Vibrio cholerae O395
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
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Multimeric state: homo dimer
Accessible surface area: 16872.95 Å2
Buried surface area: 4196.47 Å2
Dissociation area: 1,975.64 Å2
Dissociation energy (ΔGdiss): 15.86 kcal/mol
Dissociation entropy (TΔSdiss): 13.14 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-107566

Macromolecules

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Chains: A, B
Length: 244 amino acids
Theoretical weight: 26.23 KDa
Source organism: Vibrio cholerae O395
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A5F5R2 (Residues: 1-231; Coverage: 100%)
Gene names: VC0395_A1957, VC395_2494, mtnN, pfs
Pfam: Phosphorylase superfamily
InterPro:
CATH: Nucleoside phosphorylase domain
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in PDB entry 4wkb, assembly 1, front view.
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in PDB entry 4wkb, assembly 1, side view.
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in PDB entry 4wkb, assembly 1, top view.
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