4wk0

X-ray diffraction
1.78Å resolution

Metal Ion and Ligand Binding of Integrin

Released:
Source organism: Homo sapiens
Primary publication:
Metal ion and ligand binding of integrin α5β1.
Proc. Natl. Acad. Sci. U.S.A. (2014)
PMID: 25475857

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Integrin alpha-5 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 48.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08648 (Residues: 42-493; Coverage: 45%)
Gene names: FNRA, ITGA5
Sequence domains: FG-GAP repeat
Structure domains: Integrin alpha, N-terminal
Integrin beta-1 Chain: B
Molecule details ›
Chain: B
Length: 445 amino acids
Theoretical weight: 49.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05556 (Residues: 21-465; Coverage: 57%)
Gene names: FNRB, ITGB1, MDF2, MSK12
Sequence domains:
Structure domains:
ARG-GLY-ASP Chain: C
Molecule details ›
Chain: C
Length: 3 amino acids
Theoretical weight: 347 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 61.06Å b: 117.07Å c: 167.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.223
Expression systems:
  • Homo sapiens
  • Not provided