4wjx

X-ray diffraction
1Å resolution

Crystal structure of human chitotriosidase-1 catalytic domain at 1.0 A resolution

Released:

Function and Biology Details

Reaction catalysed:
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chitotriosidase-1 Chain: A
Molecule details ›
Chain: A
Length: 377 amino acids
Theoretical weight: 42.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13231 (Residues: 22-387; Coverage: 82%)
  • Best match: Q13231-2 (Residues: 22-386)
Gene name: CHIT1
Sequence domains: Glycosyl hydrolases family 18
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21212
Unit cell:
a: 85.69Å b: 105.749Å c: 41.528Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.136 0.135 0.148
Expression system: Homo sapiens