PDBe 4wj8

X-ray diffraction
2.87Å resolution

Human Pyruvate Kinase M2 Mutant C424A

Source organism: Homo sapiens
Entry authors: Mitchell T, Yuan M, McNae I, Morgan H, Walkinshaw MD

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Pyruvate kinase PKM Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 551 amino acids
Theoretical weight: 60.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P14618 (Residues: 1-531; Coverage: 100%)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 94.359Å b: 115.26Å c: 109.401Å
α: 90° β: 114.43° γ: 90°
R R work R free
0.202 0.2 0.243
Expression system: Escherichia coli