4wfh

X-ray diffraction
3.01Å resolution

Human TRAAK K+ channel in a Tl+ bound nonconductive conformation

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Potassium channel subfamily K member 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 299 amino acids
Theoretical weight: 32.57 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9NYG8 (Residues: 1-264; Coverage: 67%)
  • Best match: Q9NYG8-2 (Residues: 1-290)
Gene names: KCNK4, TRAAK
Sequence domains: Ion channel
Structure domains: Helix Hairpins
ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN Chains: D, F
Molecule details ›
Chains: D, F
Length: 211 amino acids
Theoretical weight: 23.04 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN Chains: E, G
Molecule details ›
Chains: E, G
Length: 217 amino acids
Theoretical weight: 23.47 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 80.972Å b: 138.755Å c: 96.759Å
α: 90° β: 94.64° γ: 90°
R-values:
R R work R free
0.205 0.203 0.238
Expression systems:
  • Komagataella pastoris
  • Mus musculus