X-ray diffraction
1.45Å resolution

Crystal structure of human AKR1B10 complexed with NADP+ and sulindac


Function and Biology Details

Reactions catalysed:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH
Allyl alcohol + NADP(+) = acrolein + NADPH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Aldo-keto reductase family 1 member B10 Chain: X
Molecule details ›
Chain: X
Length: 316 amino acids
Theoretical weight: 36.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O60218 (Residues: 1-316; Coverage: 100%)
Gene names: AKR1B10, AKR1B11
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

Cofactor: Ligand NAP 1 x NAP
1 bound ligand:
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P31
Unit cell:
a: 78.848Å b: 78.848Å c: 50.127Å
α: 90° β: 90° γ: 120°
R R work R free
0.189 0.188 0.207
Expression system: Escherichia coli