› 4wd5

X-ray diffraction
3.3Å resolution

Crystal structure of EGFR 696-1022 T790M in complex with QL-X138

Released:
DOI: 10.2210/pdb4wd5/pdb
PDB entry 4wd5 coloured by chain, front view.
PDB entry 4wd5 coloured by chain, side view.
PDB entry 4wd5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yun CH, Eck MJ

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 331 amino acids
Theoretical weight: 37.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 694-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 3LH 1 x 3LH
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 47.575Å b: 93.288Å c: 163.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.239
Expression system: Spodoptera frugiperda

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