4wb2

X-ray diffraction
1.8Å resolution

Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
C5a anaphylatoxin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 79 amino acids
Theoretical weight: 9.05 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P06684 (Residues: 679-755; Coverage: 5%)
Gene names: C5, Hc
Sequence domains: Anaphylotoxin-like domain
Structure domains: Anaphylotoxins (complement system)
mixed L-RNA/L-DNA mirror-image aptamer NOX-D20 (40-MER) Chains: D, E
Molecule details ›
Chains: D, E
Length: 40 nucleotides
Theoretical weight: 12.96 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P21212
Unit cell:
a: 46.47Å b: 282.254Å c: 45.899Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.167 0.193
Expression systems:
  • Escherichia coli
  • Not provided