4uzh

X-ray diffraction
2Å resolution

SAR156497 an exquisitely selective inhibitor of Aurora kinases

Released:
Source organism: Homo sapiens
Entry authors: Pouzieux S, Maignan S, Crenne JY

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 33.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O14965 (Residues: 125-399; Coverage: 68%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21
Unit cell:
a: 47.997Å b: 45.585Å c: 59.319Å
α: 90° β: 98.34° γ: 90°
R-values:
R R work R free
0.205 0.205 0.235
Expression system: Escherichia coli BL21