› 4uya

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178327 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 21 Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 38.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5TCX8 (Residues: 115-451; Coverage: 31%)
Gene names: KIAA1804, MAP3K21, MLK4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand AGS 1 x AGS
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 113.011Å b: 35.163Å c: 70.022Å
α: 90° β: 96.33° γ: 90°
R-values:
R R work R free
0.204 0.201 0.261
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Orange is the new black: Kinases are the new master regulators of tumor suppression.
An et al. (2019)
10 other articles

6 mentions without citation

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.
Marusiak et al. (2016)
5 more