X-ray diffraction
3Å resolution

Leishmania major Thymidine Kinase in complex with dTTP


Function and Biology Details

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Thymidine kinase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 191 amino acids
Theoretical weight: 21.98 KDa
Source organism: Leishmania major
Expression system: Spodoptera frugiperda
  • Canonical: Q4QC75 (Residues: 2-183; Coverage: 64%)
Gene name: LMJF_21_1210
Sequence domains: Thymidine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 61.6Å b: 61.63Å c: 110.09Å
α: 81.07° β: 85.8° γ: 74.94°
R R work R free
0.261 0.26 0.278
Expression system: Spodoptera frugiperda