Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Glial cell line-derived neurotrophic factor receptor
- GDNF/GAS1
- Transforming growth factor-beta, C-terminal
- Glial cell line-derived neurotrophic factor receptor, alpha 1
- Cystine-knot cytokine
- Cadherin-like
- Glial cell line-derived neurotrophic factor, TGF-beta-like domain
- Glial cell line-derived neurotrophic factor family
5 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-139856 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
Molecule details ›
GDNF family receptor alpha-1
Molecule details ›
Chains: C, E
Length: 463 amino acids
Theoretical weight: 51.09 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
Sequence domains: GDNF/GAS1 domain
Length: 463 amino acids
Theoretical weight: 51.09 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
- Canonical:
Q62997 (Residues: 1-468; Coverage: 99%)
Sequence domains: GDNF/GAS1 domain
Glial cell line-derived neurotrophic factor
Molecule details ›
Chains: D, F
Length: 134 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Transforming growth factor beta like domain
Length: 134 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P39905 (Residues: 78-211; Coverage: 70%)
Sequence domains: Transforming growth factor beta like domain
