4uwh

X-ray diffraction
1.93Å resolution

Function and Biology Details

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase catalytic subunit type 3 Chain: A
Molecule details ›
Chain: A
Length: 601 amino acids
Theoretical weight: 68.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NEB9 (Residues: 282-879; Coverage: 67%)
Gene names: PIK3C3, VPS34
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21212
Unit cell:
a: 88.825Å b: 145.456Å c: 61.352Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.184 0.208
Expression system: Escherichia coli BL21(DE3)