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The crystal structure of H-Ras and SOS in complex with ligands

X-ray diffraction
2.49Å resolution
PDB entry 4urx coloured by chain, front view.
PDB entry 4urx coloured by chain, side view.
PDB entry 4urx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Son of sevenless homolog 1 and GTPase HRas, N-terminally processed
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Multimeric state: hetero dimer
Accessible surface area: 28910.57 Å2
Buried surface area: 3360.94 Å2
Dissociation area: 1,596.01 Å2
Dissociation energy (ΔGdiss): 8.81 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133967

Macromolecules

GTPase HRas, N-terminally processed
Chain: R
Length: 185 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01112 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS, HRAS1
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
GTPase HRas, N-terminally processed in PDB entry 4urx, assembly 1, front view.
GTPase HRas, N-terminally processed in PDB entry 4urx, assembly 1, side view.
GTPase HRas, N-terminally processed in PDB entry 4urx, assembly 1, top view.
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Son of sevenless homolog 1
Chain: S
Length: 487 amino acids
Theoretical weight: 57.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07889 (Residues: 564-1049; Coverage: 37%)
Gene name: SOS1
Pfam:
InterPro:
CATH:
Son of sevenless homolog 1 in PDB entry 4urx, assembly 1, front view.
Son of sevenless homolog 1 in PDB entry 4urx, assembly 1, side view.
Son of sevenless homolog 1 in PDB entry 4urx, assembly 1, top view.
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