4ui0

X-ray diffraction
2.8Å resolution

Crystal structure of the human RGMB-BMP2 complex, crystal form 2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bone morphogenetic protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 114 amino acids
Theoretical weight: 12.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12643 (Residues: 283-396; Coverage: 31%)
Gene names: BMP2, BMP2A
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
RGM domain family member B Chain: C
Molecule details ›
Chain: C
Length: 96 amino acids
Theoretical weight: 10.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NW40 (Residues: 53-136; Coverage: 21%)
Gene name: RGMB

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P3221
Unit cell:
a: 85.021Å b: 85.021Å c: 115.182Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.233 0.266
Expression systems:
  • Escherichia coli BL21(DE3)
  • Homo sapiens