X-ray diffraction
1.5Å resolution

Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 22)


Function and Biology Details

Reaction catalysed:
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Glycylpeptide N-tetradecanoyltransferase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 385 amino acids
Theoretical weight: 45.08 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli BL21(DE3)
  • Canonical: A5K1A2 (Residues: 27-410; Coverage: 94%)
Gene name: PVX_085815
Structure domains: Aminopeptidase

Ligands and Environments

Cofactor: Ligand NHW 3 x NHW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 57.52Å b: 121.91Å c: 178.8Å
α: 90° β: 90° γ: 90°
R R work R free
0.217 0.214 0.261
Expression system: Escherichia coli BL21(DE3)