X-ray diffraction
2.2Å resolution

Mouse Galactocerebrosidase complexed with iso-galacto-fagomine lactam IGL


Function and Biology Details

Reaction catalysed:
D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galactocerebrosidase Chain: A
Molecule details ›
Chain: A
Length: 654 amino acids
Theoretical weight: 74.6 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
  • Canonical: P54818 (Residues: 41-684; Coverage: 100%)
Gene name: Galc
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: R32
Unit cell:
a: 249.85Å b: 249.85Å c: 77.89Å
α: 90° β: 90° γ: 120°
R R work R free
0.167 0.165 0.198
Expression system: Homo sapiens