› › Structure analysis

UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G

X-ray diffraction
3.69Å resolution
PDB entry 4uf6 coloured by chain, front view.
PDB entry 4uf6 coloured by chain, side view.
PDB entry 4uf6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 20694.19 Å2
Buried surface area: 4535.93 Å2
Dissociation area: 1,237.76 Å2
Dissociation energy (ΔGdiss): 6.55 kcal/mol
Dissociation entropy (TΔSdiss): 11.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143276
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 20916.87 Å2
Buried surface area: 4659.38 Å2
Dissociation area: 1,232.11 Å2
Dissociation energy (ΔGdiss): 3.51 kcal/mol
Dissociation entropy (TΔSdiss): 11.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143276
Assembly 3
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Multimeric state: hetero trimer
Accessible surface area: 20296.59 Å2
Buried surface area: 4390.76 Å2
Dissociation area: 1,226.08 Å2
Dissociation energy (ΔGdiss): 3.4 kcal/mol
Dissociation entropy (TΔSdiss): 11.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143276
Assembly 4
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Multimeric state: hetero trimer
Accessible surface area: 20822.59 Å2
Buried surface area: 4625.66 Å2
Dissociation area: 1,247.16 Å2
Dissociation energy (ΔGdiss): 4.41 kcal/mol
Dissociation entropy (TΔSdiss): 11.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143276

Macromolecules

Ubiquitin carboxyl-terminal hydrolase isozyme L5
Chains: A, D, G, J
Length: 331 amino acids
Theoretical weight: 37.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y5K5 (Residues: 1-329; Coverage: 100%)
Gene names: AD-019, CGI-70, UCH37, UCHL5
Pfam:
InterPro:
Ubiquitin carboxyl-terminal hydrolase isozyme L5 in PDB entry 4uf6, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase isozyme L5 in PDB entry 4uf6, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase isozyme L5 in PDB entry 4uf6, assembly 1, top view.
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Ubiquitin
Chains: B, E, H, K
Length: 76 amino acids
Theoretical weight: 8.56 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P0CG47 (Residues: 153-227; Coverage: 33%)
Gene name: UBB
Pfam: Ubiquitin family
InterPro:
Ubiquitin in PDB entry 4uf6, assembly 1, front view.
Ubiquitin in PDB entry 4uf6, assembly 1, side view.
Ubiquitin in PDB entry 4uf6, assembly 1, top view.
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Nuclear factor related to kappa-B-binding protein
Chains: C, F, I, L
Length: 65 amino acids
Theoretical weight: 7.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6P4R8 (Residues: 40-101; Coverage: 5%)
Gene names: INO80G, NFRKB
InterPro:
Nuclear factor related to kappa-B-binding protein in PDB entry 4uf6, assembly 1, front view.
Nuclear factor related to kappa-B-binding protein in PDB entry 4uf6, assembly 1, side view.
Nuclear factor related to kappa-B-binding protein in PDB entry 4uf6, assembly 1, top view.
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