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X-ray structure and activities of an essential Mononegavirales L- protein domain

X-ray diffraction
2.66Å resolution
PDB entry 4uck coloured by chain, front view.
PDB entry 4uck coloured by chain, side view.
PDB entry 4uck coloured by chain, top view.
Source organism: Human metapneumovirus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Large structural protein
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-187522
Assembly 2
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Assembly Name: Large structural protein
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-187522

Macromolecules

Large structural protein
Chains: A, B
Length: 415 amino acids
Theoretical weight: 47.66 KDa
Source organism: Human metapneumovirus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q91L20 (Residues: 1600-2005; Coverage: 20%)
Gene name: L
Pfam: Virus-capping methyltransferase, MT domain
InterPro: Mononegavirus L protein 2-O-ribose methyltransferase
Replicase in PDB entry 4uck, assembly 1, front view.
Replicase in PDB entry 4uck, assembly 1, side view.
Replicase in PDB entry 4uck, assembly 1, top view.
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