4ucd

X-ray diffraction
2.66Å resolution

N-terminal globular domain of the RSV Nucleoprotein in complex with the Nucleoprotein Phosphoprotein interaction inhibitor M81

Released:
Entry authors: Ouizougun-Oubari M, Pereira N, Tarus B, Galloux M, Tortorici M-A, Hoos S, Baron B, England P, Bontems F, Rey FA, Eleouet J-F, Sizun C, Slama-Schwok A, Duquerroy S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 233 amino acids
Theoretical weight: 26.27 KDa
Source organism: Human respiratory syncytial virus A2
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P03418 (Residues: 31-252; Coverage: 57%)
Gene name: N
Sequence domains: Pneumovirus nucleocapsid protein

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 34.68Å b: 71.94Å c: 178.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.174 0.215
Expression system: Escherichia coli BL21