› 4ucd

X-ray diffraction
2.66Å resolution

N-terminal globular domain of the RSV Nucleoprotein in complex with the Nucleoprotein Phosphoprotein interaction inhibitor M81

Released:
DOI: 10.2210/pdb4ucd/pdb
PDB 4ucd coloured by chain and viewed from the front.
PDB 4ucd coloured by chain and viewed from the side.
PDB 4ucd coloured by chain and viewed from the top.
Source organism: Human respiratory syncytial virus A2
Entry authors: Ouizougun-Oubari M, Pereira N, Tarus B, Galloux M, Tortorici M-A, Hoos S, Baron B, England P, Bontems F, Rey FA, Eleouet J-F, Sizun C, Slama-Schwok A, Duquerroy S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 233 amino acids
Theoretical weight: 26.27 KDa
Source organism: Human respiratory syncytial virus A2
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P03418 (Residues: 31-252; Coverage: 57%)
Gene name: N
Sequence domains: Pneumovirus nucleocapsid protein

Ligands and Environments

2 bound ligands:
Ligand M81 2 x M81
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 34.68Å b: 71.94Å c: 178.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.174 0.215
Expression system: Escherichia coli BL21

Quick links

Citations

12 review citations

Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals.
Decool et al. (2021)
11 more