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Crystal structure of CXCL12 in complex with inhibitor

X-ray diffraction
1.9Å resolution
PDB entry 4uai coloured by chain, front view.
PDB entry 4uai coloured by chain, side view.
PDB entry 4uai coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Stromal cell-derived factor 1
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Multimeric state: homo dimer
Accessible surface area: 8986.57 Å2
Buried surface area: 2451.19 Å2
Dissociation area: 1,048.09 Å2
Dissociation energy (ΔGdiss): 4.77 kcal/mol
Dissociation entropy (TΔSdiss): 10.81 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-155706

Macromolecules

Stromal cell-derived factor 1
Chains: A, B
Length: 68 amino acids
Theoretical weight: 7.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48061 (Residues: 22-89; Coverage: 94%)
Gene names: CXCL12, SDF1, SDF1A, SDF1B
Pfam: Small cytokines (intecrine/chemokine), interleukin-8 like
InterPro:
CATH: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Stromal cell-derived factor 1 in PDB entry 4uai, assembly 1, front view.
Stromal cell-derived factor 1 in PDB entry 4uai, assembly 1, side view.
Stromal cell-derived factor 1 in PDB entry 4uai, assembly 1, top view.
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