› 4u6g

X-ray diffraction
4.2Å resolution

Crystal structure of 10E8 Fab in complex with a hydrocarbon-stapled HIV-1 gp41 MPER peptide

Released:
DOI: 10.2210/pdb4u6g/pdb
PDB 4u6g coloured by chain and viewed from the front.
PDB 4u6g coloured by chain and viewed from the side.
PDB 4u6g coloured by chain and viewed from the top.
Source organisms:
Entry authors: Ofek G, Bird GH, Walensky LD, Kwong PD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
10E8 Fab Heavy Chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 236 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
10E8 Fab Light Chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 215 amino acids
Theoretical weight: 22.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Envelope glycoprotein Chains: C, P
Molecule details ›
Chains: C, P
Length: 17 amino acids
Theoretical weight: 2.19 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: I3VHW6 (Residues: 126-141; Coverage: 9%)
Gene name: env

Ligands and Environments

No bound ligands
2 modified residues:
Ligand DIV 2 x DIV
Ligand MK8 2 x MK8

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 68.562Å b: 126.317Å c: 129.875Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.281
Expression systems:
  • Homo sapiens
  • Not provided

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