4u6a

X-ray diffraction
2.37Å resolution

X-ray crystal structure of human TNKS in complex with a small molecule inhibitor

Released:
Source organism: Homo sapiens
Entry author: Oliver AW

Function and Biology Details

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase tankyrase-1 Chain: A
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 29.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95271 (Residues: 1091-1325; Coverage: 18%)
Gene names: PARP5A, PARPL, TIN1, TINF1, TNKS, TNKS1
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain
Structure domains: Phosphoenolpyruvate Carboxykinase; domain 3

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: I212121
Unit cell:
a: 81.38Å b: 80.98Å c: 84.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.248
Expression system: Escherichia coli BL21(DE3)