4u45

X-ray diffraction
2.58Å resolution

MAP4K4 in complex with inhibitor (compound 25)

Released:
Source organism: Homo sapiens
Entry authors: Harris SF, Wu P, Coons M

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
monomeric
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase kinase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 332 amino acids
Theoretical weight: 37.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O95819 (Residues: 2-328; Coverage: 26%)
Gene names: HGK, KIAA0687, MAP4K4, NIK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 79.915Å b: 89.018Å c: 91.396Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.244
Expression system: Spodoptera frugiperda