PDBe 4tz8

X-ray diffraction
2.15Å resolution

Structure of human ATAD2 bromodomain bound to fragment inhibitor

Released:
Source organism: Homo sapiens
Primary publication:
Fragment-based screening of the bromodomain of ATAD2.
OpenAccess logo J. Med. Chem. (2014)
PMID: 25314628

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase family AAA domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6PL18 (Residues: 981-1108; Coverage: 9%)
Gene names: ATAD2, L16, PRO2000
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P6522
Unit cell:
a: 79.942Å b: 79.942Å c: 138.259Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.198 0.231
Expression system: Escherichia coli BL21(DE3)