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Crystal structure of uridine phosphorylase from Schistosoma mansoni in complex with thymine

Source organism: Schistosoma mansoni
Biochemical function: identical protein binding
Biological process: UMP salvage
Cellular component: cytosol

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EC 2.4.2.3: Uridine phosphorylase

Reaction catalysed:
Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
Systematic name:
Uridine:phosphate alpha-D-ribosyltransferase
Alternative Name(s):
  • Pyrimidine phosphorylase
  • UPH
  • UPase
  • UrdPase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01048
Domain description: Phosphorylase superfamily
Occurring in:
  1. Uridine phosphorylase A
The deposited structure of PDB entry 4txm contains 2 copies of Pfam domain PF01048 (Phosphorylase superfamily) in Uridine phosphorylase A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR010059
Domain description: Uridine phosphorylase, eukaryotic
Occurring in:
  1. Uridine phosphorylase A
IPR035994
Domain description: Nucleoside phosphorylase superfamily
Occurring in:
  1. Uridine phosphorylase A
IPR000845
Domain description: Nucleoside phosphorylase domain
Occurring in:
  1. Uridine phosphorylase A

Structure domain

CATH CATH domain
3.40.50.1580
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Nucleoside phosphorylase domain
Occurring in:
  1. Uridine phosphorylase A
The deposited structure of PDB entry 4txm contains 2 copies of CATH domain 3.40.50.1580 (Rossmann fold) in Uridine phosphorylase A. Showing 1 copy in chain A.

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