X-ray diffraction
2.5Å resolution

X-ray crystal structure of CYP119 from Sulfolobus acidocaldarius, complexed with 4-(4-chlorophenyl)imidazole

Entry author: Madrona Y

Function and Biology Details

Reaction catalysed:
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cytochrome P450 119 Chain: A
Molecule details ›
Chain: A
Length: 368 amino acids
Theoretical weight: 42.92 KDa
Source organism: Sulfolobus acidocaldarius DSM 639
Expression system: Escherichia coli
  • Canonical: Q55080 (Residues: 1-368; Coverage: 100%)
Gene names: Saci_2081, cyp119
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

Cofactor: Ligand HEM 1 x HEM
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P6322
Unit cell:
a: 165.8Å b: 165.8Å c: 75.86Å
α: 90° β: 90° γ: 120°
R R work R free
0.19 0.188 0.239
Expression system: Escherichia coli