4tuu

X-ray diffraction
2.64Å resolution

Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 57.689Å b: 136.447Å c: 143.083Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.245
Expression system: unidentified baculovirus