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Structure of the apo form of InhA from Mycobacterium tuberculosis

X-ray diffraction
1.8Å resolution
PDB entry 4trm coloured by chain, front view.
PDB entry 4trm coloured by chain, side view.
PDB entry 4trm coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Enoyl-[acyl-carrier-protein] reductase [NADH]
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Multimeric state: homo tetramer
Accessible surface area: 35340.92 Å2
Buried surface area: 14090.16 Å2
Dissociation area: 3,924.3 Å2
Dissociation energy (ΔGdiss): 60.05 kcal/mol
Dissociation entropy (TΔSdiss): 15.02 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-161512
Assembly 2
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Assembly Name: Enoyl-[acyl-carrier-protein] reductase [NADH]
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Multimeric state: homo tetramer
Accessible surface area: 32762.36 Å2
Buried surface area: 14082.1 Å2
Dissociation area: 4,091.9 Å2
Dissociation energy (ΔGdiss): 59.89 kcal/mol
Dissociation entropy (TΔSdiss): 14.99 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-161512

Macromolecules

Enoyl-[acyl-carrier-protein] reductase [NADH]
Chains: A, B, C, D, E, F
Length: 269 amino acids
Theoretical weight: 28.55 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P9WGR1 (Residues: 1-269; Coverage: 100%)
Gene names: MTCY277.05, Rv1484, inhA
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
Enoyl-[acyl-carrier-protein] reductase [NADH] in PDB entry 4trm, assembly 1, front view.
Enoyl-[acyl-carrier-protein] reductase [NADH] in PDB entry 4trm, assembly 1, side view.
Enoyl-[acyl-carrier-protein] reductase [NADH] in PDB entry 4trm, assembly 1, top view.
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