› 4tpv

X-ray diffraction
1.6Å resolution

Crystal Structure of Hookworm Platelet Inhibitor

Released:
DOI: 10.2210/pdb4tpv/pdb
PDB entry 4tpv coloured by chain, front view.
PDB entry 4tpv coloured by chain, side view.
PDB entry 4tpv coloured by chain, top view.
Source organism: Ancylostoma caninum
Primary publication:
The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum.
Ma D, Francischetti IM, Ribeiro JM, Andersen JF
Acta Crystallogr F Struct Biol Commun 71 643-9 (2015)
PMID: 26057788

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-188299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hookworm platelet inhibitor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 182 amino acids
Theoretical weight: 20.59 KDa
Source organism: Ancylostoma caninum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q962V9 (Residues: 20-198; Coverage: 99%)
Gene name: ANCCAN_03259
Sequence domains: Cysteine-rich secretory protein family
Structure domains: CAP

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 39.158Å b: 51.985Å c: 73.94Å
α: 90° β: 90.05° γ: 90°
R-values:
R R work R free
0.152 0.15 0.194
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Beyond the Matrix: The Many Non-ECM Ligands for Integrins.
LaFoya et al. (2018)
1 more

3 mentions without citation

Regulation of Functional Protein Aggregation by Multiple Factors: Implications for the Amyloidogenic Behavior of the CAP Superfamily Proteins.
Sheng et al. (2020)
2 more