X-ray diffraction
2.6Å resolution

Crystal Structure of the Human LIMK2 Kinase Domain In Complex With a Non-ATP Competitive Inhibitor


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
LIM domain kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 303 amino acids
Theoretical weight: 34.58 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
  • Canonical: P53671 (Residues: 330-632; Coverage: 48%)
Gene name: LIMK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 51.569Å b: 77.903Å c: 86.387Å
α: 90° β: 100.84° γ: 90°
R R work R free
0.223 0.22 0.274
Expression system: unidentified baculovirus