X-ray diffraction
2.9Å resolution

West Nile Virus Non-structural protein 1 (NS1) Form 1 crystal

Source organism: West Nile virus
Entry authors: Akey DL, Smith JL

Function and Biology Details

Reactions catalysed:
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
West Nile Virus NS1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 377 amino acids
Theoretical weight: 42.61 KDa
Source organism: West Nile virus
Expression system: Trichoplusia ni
  • Canonical: Q5SBG8 (Residues: 791-1143; Coverage: 10%)
Sequence domains: Flavivirus non-structural Protein NS1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P321
Unit cell:
a: 167.85Å b: 167.85Å c: 93.73Å
α: 90° β: 90° γ: 120°
R R work R free
0.172 0.17 0.21
Expression system: Trichoplusia ni