X-ray diffraction
3.91Å resolution

Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2


Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proton:oligopeptide symporter POT family Chains: A, B
Molecule details ›
Chains: A, B
Length: 523 amino acids
Theoretical weight: 57.22 KDa
Source organism: Shewanella oneidensis MR-1
Expression system: Escherichia coli
  • Canonical: Q8EHE6 (Residues: 1-516; Coverage: 100%)
Gene name: SO_1277
Sequence domains: POT family
Structure domains: MFS general substrate transporter like domains
Ala-L-3-Br-Tyr-Ala Chain: E
Molecule details ›
Chain: E
Length: 3 amino acids
Theoretical weight: 481 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 82.89Å b: 108.09Å c: 206.83Å
α: 90° β: 90° γ: 90°
R R work R free
0.262 0.261 0.29
Expression systems:
  • Escherichia coli
  • Not provided