› 4toy

X-ray diffraction
1.55Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
35O22 Fab Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 243 amino acids
Theoretical weight: 26.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
35O22 Fab Light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P41212
Unit cell:
a: 57.183Å b: 57.183Å c: 267.677Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.166 0.182
Expression system: Homo sapiens

Quick links

Citations

69 review citations

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention.
Kwon et al. (2021)
68 more

11 mentions without citation

Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies.
Zhang et al. (2016)
10 more