X-ray diffraction
2.55Å resolution

Structural basis of cellular dNTP regulation, SAMHD1-GTP-dTTP-dTTP complex

Source organism: Homo sapiens
Primary publication:
Structural basis of cellular dNTP regulation by SAMHD1.
Proc. Natl. Acad. Sci. U.S.A. (2014)
PMID: 25267621

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 514 amino acids
Theoretical weight: 59.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y3Z3 (Residues: 113-626; Coverage: 82%)
Gene names: MOP5, SAMHD1
Sequence domains: HD domain
Structure domains: Hypothetical protein af1432

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 81.159Å b: 140.292Å c: 97.268Å
α: 90° β: 114.56° γ: 90°
R R work R free
0.163 0.161 0.198
Expression system: Escherichia coli