› 4tnf

X-ray diffraction
1.6Å resolution

Crystal Structure of Human Transthyretin Lys15Trp Mutant

Released:
DOI: 10.2210/pdb4tnf/pdb
PDB 4tnf coloured by chain and viewed from the front.
PDB 4tnf coloured by chain and viewed from the side.
PDB 4tnf coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Saelices L, Cascio D, Sawaya M, Eisenberg DS

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 29-147; Coverage: 94%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand OCS 2 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 42.92Å b: 85.61Å c: 64.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.213
Expression system: Escherichia coli BL21(DE3)

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